Faculty
Chen, Ye
Du, Xinjun
Fan, Zhenchuan
Fang, Guozhen
Guo, Qingbin
Hou, Lihua
Liu, Huiping
Liu, Jifeng
Liu, Xia
Liu, Yaqing
Lu, Xiaoling
Sheng, Wei
Wang, Changlu
Wang, Chunling
Wang, Junping
Wang, Lixia
Wang, Shujun
Wang, Wenhang
Wang, Yanping
Yu, Jinghua
Zhang, Min
Zhang, Zesheng
Zhao, Jiang
Zhou, Zhongkai
Zhu, Zhenyuan
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Zhu, Zhenyuan

 

Zhenyuan  Zhu

Ph.D, Professor

address:

Room 305, Yifulou Building, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology, TEDA, Tianjin, 300457, China

email:

zhyuanzhu@tust.edu.cn; zhyuanzhu@hotmail.com

phone:

+86 022-60912390

Education

1989.9-1993.7,    BSc of biology, Central China Normal University, Wuhan, Hubei, P. R. China

1996.9-1999.7,    MSc of Microbiology, Guizhou University, Guiyang, P.R.China

1999.9-2003.9,    PhD of plant pathology, Zhejiang University, Hangzhou, P.R.China

2001.10-2005.10, PhD of Molecular chemistry, University of Paris VI (Pierre-and-Marie-Curie University),  Paris, France

  

Professional Experiences

2005.5-2005.9, Visiting scholar of Division of Biomembrane Research, Pacific Northwest Research Institute, Univ. of WashingtonSeattle, United States

2006.3-2011.10, Associate Professor of College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R.China

2008.7-2008.10, Visiting scholar of University of Paris VI (Pierre-and-Marie-Curie University),  Paris, France

2011.11-present, Professor of College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin ,300457, P.R.China

  

  

Research Interests

The research interests are in the understanding the structures and functions of the complex carbohydrates in foods, to determine the role of carbohydrates in growth and development, host-pathogen interactions, and disease processes. We develop and use advanced analytical techniques, including mass spectrometry, NMR spectroscopy, chemical and enzymatic synthesis, cell and molecular biology, and immunocytochemistry.

 Recent Publications

(1)Ren Yuan-Yuan; zhu zhenyuan(*); Sun Hui-Qing; Chen Li-Jing(*), Structural characterization and inhibition on alpha-glucosidase activity of acidic polysaccharide from Annona squamosa, Carbohydrate polymers, 2017.10.15, 174: 1~12   

(2)Yu Na; Zhu Zhen-Yuan(*); Liu Yao; Zhang Jin-Yu; Zhang Yong-Min, Chromatographic analysis and preparation of L-arabinose from corncob by acid hydrolysis, INDUSTRIAL CROPS AND PRODUCTS, 2017.1.1, 95: 163~169 

(3)Zhu Zhen-Yuan(#)(*); Meng Meng; Sun Huiqing; Li Yang; Ren Yuan-Yua; Zhang, Yongmin, Immunostimulatory activity of glycopeptides from Paecilomyces sinensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models, FOOD & FUNCTION,2016.08.01, 7(8): 3566~3576)

(4)Wang Xiao-Ting; Zhu Zhen-Yuan(*); Zhao Liang; Sun Hui-Qing; Meng Meng; Zhang Jin-Yu; Zhang Yong-min, Structural characterization and inhibition on alpha-D-glucosidase activity of non-starch polysaccharides from Fagopyrum tartaricum, CARBOHYDRATE POLYMERS,2016.11.01, 153: 679~685 

(5)Liu Xiao-Cui; Zhu Zhen-Yuan(*); Tang Ya-Li; Wang, Ming-fei; Wang Zheng; Liu An-Jun; Zhang, Yong-Min, Structural properties of polysaccharides from cultivated fruit bodies and mycelium of Cordyceps militaris, CARBOHYDRATE POLYMERS, 2016.05.20, 142: 63~72

(6)Zhen-YuanZhu(#)(*); Meng Meng; Huiqing Sun; Yang Li; NaYu; Yong-Min Zhang, Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis, Food & Function, 2016.2.16, 7(3): 1593~1600

(7)Xiao-Cui Liu(#)Zhen-Yuan(*); Ya-Li Tang; Ming-fei Wang; Zheng Wang; An-Jun Liu; Yong-Min Zhang, Structural properties of polysaccharides from cultivated fruit bodies and mycelium of Cordyceps militaris, Carbohydrate Polymers, 2016.1.15, 142: 63~72

(8)Zhen-Yuan Zhu(#)(*); Xiao-Cui Liu; Feng-Ying Dong; Ming-Zhu Guo; Xiao-Ting Wang; Zheng Wang; Yong-Min Zhang, Influence of fermentation conditions on polysaccharid production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris, Appl Microbiol Biotechnol, 2015.12.19, 100(9): 3909~3921

(9)Zhenyuan Zhu(#)(*); Di Cui; Hui Gao; Fengying Dong; Xiaocui Liu; Fei Liu; Lu Chen; Yongming Zhang, Efficient synthesis and activity of beneficial intestinal flora of two lactulose-derived oligosaccharides, European Journal of Medicinal Chemistry, 2016.5.23,114: 8~13

(10)Zhen-yuan Zhu(#)(*); Fengying Dong; Xiaocui Liu; Qian Lv; YingYang; Fei Liu; Ling Chen; iantian Wang; ZhengWang; Yongmin Zhang,Effects of extraction methods on the yield, chemical structure and anti-tumor activity of polysaccharides from Cordyceps gunnii mycelia,Carbohydrate Polymers, 2016.1.5, 140: 461~471

(11)Sun Hui-Qing; Zhu Zhen-Yuan(*); Yang Xue-Ying); Meng Meng; Dai Li-Cui; Zhang Yong-Min, Preliminary characterization and immunostimulatory activity of a novel functional polysaccharide from Astragalus residue fermented by Paecilomyces sinensis, RSC ADVANCES,2017.5.1, 7(38): 23875~238811

(12)Liu Fei; zhu zhenyuan(*); Sun Xiaoli; Gao Hui; Zhang Yong-Min, The preparation of three selenium-containing Cordyceps militaris polysaccharides: Characterization and anti-tumor activities, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017.06.01, 99: 196-2041

(13)Zhu, Zhen-Yuan(#)(*); Zhang, Jin-Yu; Liu, Fei; Chen, Ling; Chen, Li-Jing; Tang, Yun, Characterization and lymphocyte proliferation activity of an oligosaccharide degraded from Astragalus polysaccharide, MEDCHEMCOMM, 2017.7.1, 8(7): 1521~1530

(14)Liu Wen-Bin; (Xie Fei; Sun Hui-Qing; (Meng Meng; Zhu Zhen-Yuan(*), Anti-tumor effect of polysaccharide from Hirsutella sinensis on human non-small cell lung cancer and nude mice through intrinsic mitochondrial pathway, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017.6.1, 99: 196~204

(15)Zhu Zhen-Yuan(#)(*); Chen Ling; Liu Fei; Chen Li-Jing; Meng Meng; Sun Hui-Qing; Zhang Yong-Min, Preparation and activity evaluation of chrysin-beta-D-galactopyranoside, ARCHIVES OF PHARMACAL RESEARCH, 2016.10.1, 39(10): 1433~1440   

(16)Zhu, Zhen-Yuan(#)(*); Liu Xiao-Cui; Tang Ya-Li; Dong Feng-Ying; Sun Hui-Qing; Chen, Lu; Zhang Yong-Min, Effects of cultural medium on the formation and antitumor activity of polysaccharides by Cordyceps gunnii, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2016.10.01,122(4): 494~498   

(17)Zhu Zhen-Yuan(#)(*); Liu Fei; Gao Hui; Sun Huiqing; Meng Meng; Zhang Yong-Min, Synthesis, characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016.12.1, 93: 1090~1099 

(18)Zhu Zhen-Yuan(#)(*); Guo Ming-Zhu; Liu Fei; Luo You; Chen Lu; Meng Meng; Wang Xiao-Ting; Zhang Yong-Min, Preparation and inhibition on alpha-D-glucosidase of low molecular weight polysaccharide from Cordyceps militaris, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016.12.01, 93: 27~33  

(19)Zhu Zhen-Yuan(#)(*); Luo You; Dong Guo-Ling; Ren Yuan-Yuan; Chen, Li-Jing; Guo Ming-Zhu; Wang Xiao-Ting; Yang, Xue-Ying; Zhang Yongmin, Effects of the ultra-high pressure on structure and alpha-glucosidase inhibition of polysaccharide from Astragalus,INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016.06.01, 87: 570~576  

(20)Zhen-Yuan Zhu(#)(*); You Luo; Yang Liu; Xiao-Ting Wang; Fei Liu; Ming-Zhu Guo; Zheng Wang; An-Jun Liu; Yong-Min Zhang, Inclusion of chrysinin b-cyclodextrin and its biological activities, Journal of Drug Delivery Science and Technology, 2016.1.20, 31: 176~186 

(21)Zhen-Yuan Zhu(#)(*); Xiao-Cui Liu; Xiao-Na Fang; Hui-Qing Sun; Xue-Ying Yang; Yong-Min Zhang, Structural characterization and anti-tumor activity of polysaccharide produced by Hirsutella sinensis, International Journal of Biological Macromolecules, 2016.1.10, 82: 959~966 

(22)Zhen-Yuan Zhu(#)(*); Liang Zhao; Xiao‑Ran Ge; Ya‑Li Tang; Li‑Jing Chen; Wei Pang; Yongmin Zhang, Preparation,characterization and bioactivity of xylobiose and xylotriose from corncob xylanby xylanase, European Food Research and Technology, 2015.2.26, 241: 27~35  

(23)Zhen-Yuan Zhu(#)(*); Wan-Xiao Wang; Zhen-qian Wang; Li-Jing Chen; Jing-Yi Zhang; Xiao-cui Liu; Shao-ping Wu; Yong-min Zhang,Synthesis and antitumor activity evaluation of chrysin derivatives, European Journal of Medicinal Chemistry, 2014.3.21, 75: 297~300  

(24)Zhen-Yuan Zhu(#)(*); Wei Pang; Yuan-Yuan Li; Xiao-Ran Ge; Li-Jing Chen; Xiao-Cui Liu; Qiang Lv; Guo-Ling Dong; An-Jun Liu; Yongmin Zhang, Effect of ultrasonic treatment on structure and antitumor activity of mycelial polysaccharides from Cordyceps gunnii,Carbohydrate Polymers, 2014.12.19, 114: 12~20  

(25)Zhen-Yuan ZHU(#)(*); Jing-Yi ZHANG; Li-Jing CHEN; Xiao-Cui LIU; Yang LIU; Wan-Xiao WANG; Yong-Min ZHANG, Comparative evaluation of polysaccharides isolated from Astragalus, oyster mushroom, and yacon as inhibitors of α-glucosidase, Chinese Journal of Natural Medicines, 2014.4, 12(4): 290~293   

(26)Zhu, Zhen-Yuan(#)(*); Liu, Yang; Si, Chuan-Ling; Yuan, Jing; Lv, Qiang; Li, Yuan-Yuan; Dong, Guo-Ling; Liu, An-Jun; Zhang, Yong-Min, Sulfated modification of the polysaccharide from Cordyceps_gunnii mycelia and its biological activities, CARBOHYDRATE POLYMERS,2013.1.30, 92(1): 872~876  

(27)Zhu, Zhen-Yuan(#)(*); Chen, Jing; Si, Chuan-Ling; Liu, Nian; Lian, Hong-Yu; Ding, Li-Na; Liu, Yang; Zhang, Yong-Min,Immunomodulatory effect of polysaccharides from submerged cultured Cordyceps gunnii, Pharmaceutical Biology, 2012.9, 50(9): 1103~1110

(28)Zhu, Zhen-Yuan(#)(*); Liu, Nian; Liu, Yang; Si, Chuan-Ling; Liu, Rong-Qiang; Chen, Jing; Liu, Chang-Jin; Liu, An-Jun; Zhang, Yong-Min, Chemical analysis of a polysaccharide from Cristaria plicata (Leach), International Journal of Food Sciences and Nutrition,2012.6, 63(4): 506~511

(29)Zhu, Zhen-yuan(#)(*); Liu, Nian; Si, Chuan-ling; Liu, Yang; Ding, Li-na; Jing, Chen; Liu, An-jun; Zhang, Yong-min, Structure and anti-tumor activity of a high-molecular-weight polysaccharide from cultured mycelium of Cordyceps gunnii, Carbohydrate Polymers,2012.4.15, 88(3): 1072~1076 

(30)Zhu, Zhen-Yuan(#)(*); Liu, Nian; Liu, Yang; Si, Chuan-Ling; Liu, Rong-Qiang; Chen, Jing; Liu, Chang-Jin; Liu, An-Jun; Zhang, Yong-Min, Chemical analysis of a polysaccharide from Cristaria plicata (Leach)., International Journal of Food Sciences and Nutrition,2012.6, 63(4): 506~511 

(31)Zhu, Zhen-Yuan(#)(*); Yao, Qiang; Liu, Yang; Si, Chuan-Ling; Chen, Jing; Liu, Nian; Lian, Hong-Yu; Ding, Li-Na; Zhang, Yong-Min,Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis., Journal of Asian Natural Products Research, 2012, 14(5): 429~435 

(32)Zhu, Zhen-Yuan(#)(*); Chen, Jing; Si, Chuan-Ling; Liu, Nian; Lian, Hong-Yu; Ding, Li-Na; Liu, Yang; Zhang, Yong-Min,Immunomodulatory effect of polysaccharides from submerged cultured Cordyceps gunnii., Pharmaceutical Biology, 2012.9, 50(9): 1103~1110  

(33)Zhu, Zhen-Yuan(#)(*); Lian, Hong-Yu; Si, Chuan-Ling; Liu, Yang; Liu, Nian; Chen, Jing; Ding, Li-Na; Yao, Qiang; Zhang, Yongmin,The chromatographic analysis of oligosaccharides and preparation of 1-kestose and nystose in yacon, International Journal of Food Sciences and Nutrition, 2012.5, 63(3): 338~342  

(34)Zhu, Zhen-Yuan(#)(*); Yao, Qiang; Liu, Yang; Si, Chuan-Ling; Chen, Jing; Liu, Nian; Lian, Hong-Yu; Ding, Li-Na; Zhang, Yong-Min,Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis, Journal of Asian Natural Products Research, 2012, 14(5): 429~435 

(35)Liu, Anjun; Sun, Kezhuang; Zhu, Zhen-Yuan(*); Fan, Yanli, Preparation and Structural Characterization of L-Arginine-selenic Acid Addition Compound, ASIAN JOURNAL OF CHEMISTRY, 2012.10, 24(10): 4819~4820  

(36)Zhenyuan Zhu(#)(*); Rongqiang Liu; Chuangling Si; Fan Zhou; Yunxia Wang; Lina Ding; Jing Chen; Anjun Liu; Yongming Zhang,Structural analysis and anti-tumor activity comparison of polysaccharides from Astragalus , Carbohydrate Polymers, 2011.6.1, 85: 895~902