Yifulou Building, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology, TEDA, Tianjin, 300457, China
email:
wangshuai@tust.edu.cn
phone:
+86 022-60912431
Biography
Dr. Wang started her research from master period at Nankai University under the supervision of Prof. Peng G. Wang, a world leading scientist in chem-enzymatic oligosaccharides syntheses. She received research training in chemical & enzymatic synthesis of oligosaccharides and analogues and systematic analysis assay for monitoring glycosyltransferase enzyme activity. Dr. Wang then pursued her Ph.D. degree at Université Claude Bernard Lyon 1, France. Due to her academic excellence, she was awarded an international scholarship from French Ministère de l’Enseignement Supérieur et de la Recherche for supporting her research. Her work mainly focused on the design and synthesis of neutral glycosyltransferase inhibitors in Prof. Sebastien Vidal’s group. Thanks to the collaboration with Prof. Palcic in the Carlsberg Laboratory, Denmark, Dr. Wang received a comprehensive training in radiometric assay methods to screen her library of compounds. To extend her research fields, Dr. Wang then carried out her postdoctoral research with Profs. Vidal, Poisson, Andraud and Bretonniere at the Université Claude Bernard Lyon 1, the Université Joseph Fournier Grenoble and at the Ecole Normale Superieure in Lyon. Her work has led to a large number of very important publications. Since Sep. 2017, Dr. WANG is working at college of Food Engineering and Biotechnology, Tianjin University of Science and Technology.
Research Interests
1. Flavor Chemistry
2. Carbohydrate-related Mechanisms
3. Glycochemistry & Glycobiology
Recent Publications
1) Angeli A., Li M., Dupin L., Vergoten G., Noël M., Madaoui M., Wang S., Meyer A., Gehin T., Vidal S., Vasseur J-J., Chevolot Y., Morvan F. “Design and synthesis of galactosylated bifurcated ligands with nanomolar affinity for lectin LecA from Pseudomonas aeruginosa” ChemBioChem, 2017, 18, 1036-1047.
2) Wang S., Dupin L., Noël M., Carroux C. J., Renaud L., Meyer A., Souteyrand E., Vasseur J-J., Vergoten G., Chevolot Y., Morvan F., Vidal S. “Toward the rational design of galactosylated glycoclusters that target Pseudomonas aeruginosa Lectin A (LecA): influence of linker arms that lead to low-nanomolar multivalent ligands” Chem. Eur. J., 2016, 22, 11785-11794.
3) Wang S., Cuesta-Seijo J. A., Striebeck A., Lafont D., Palcic M. M., Vidal S. “Design of glycosyltransferase inhibitors: serine analogues as pyrophosphate surrogates?” ChemPlusChem, 2015, 80, 1525-1532.
4) Wang S., Galanos N., Rousset A., et al. “Fucosylation of triethyleneglycol-based acceptors into “clickable” α-fucosides” Carbohydr. Res., 2014, 395, 15-18.
5) Wang S., Shen D. L., Lafont D., Vercoutter-Edouart A-S., Mortuaire M., Shi Y., Maniti O., Girard-Egrot A., Lefebvre T., Pinto B. M., Vocadlo D., and Vidal S. “Design of glycosyltransferase inhibitors targeting human O-GlcNAc Transferase (OGT)” MedChemComm, 2014, 5, 1172-1178.
6) Wang S., Cuesta-Seijo J. A., Lafont D., Palcic M. M., and Vidal S. “Design of glycosyltransferase inhibitors: Pyridine as a pyrophosphate surrogate” Chem. Eur. J., 2013, 19, 15346-15357.
7) Wang S., Lafont D., Rahkila J., Picod B., Leino R. and Vidal S. “Glycosylation of 'basic' alcohols: methyl 6-(hydroxymethyl)picolinate as a case study” Carbohydr. Res., 2013, 372, 35-46.
