Biography

Dr. Huanhuan Liu is a lecturer of the college of Food Engineering and Biotechnology, Tianjin University of Science and Technology (TUST). Dr. Liu completed his Bachelor, Master and Doctor Degrees from Tianjin University at 2011, 2014 and 2017. He joined TUST as a lecture at August 2017. He has published 9 scientific papers.

Research Interests

The lignocellulosic hydrolysate is the hot research field in the bio-production of important industrial platform chemicals. Dr. Liu has been working on the investigation of the responding mechanism of Clostridium acetobutylicum exposing to the inhibitors, such as  phenolic compounds, furfurals and weak acids produced during the hydrolysation process lignocellulosic material. Dr. Liu is good at the application of “OMICS” tools, such as transcriptomics, proteomics and metanolomics. Besides, the production of  the industry-level D-lactic acid, FK506 (tacrolimus) and 4-hydroxycyclosporinl A are also the research interests of Dr Liu.

Recent Publications

[1]  Liu H, Di H, Wen J. Integrated intracellular metabolic profiling and pathway analysis approaches reveal complex metabolic regulation by Clostridium acetobutylicum. [J]. Microbial Cell Factories, 2016, 15(1):1-14.

[2]  Liu H, Huang D, Jin L, et al. Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4'-OH)MeLeu]4-CsA overproduction.[J]. Microbial Cell Factories, 2017, 16(1):120.

[3]  Pan X, Liu H (co-first author), Liu J, et al. Omics-based approaches reveal phospholipids remodeling of Rhizopus oryzae responding to furfural stress for fumaric acid-production from xylose [J]. Bioresource Technology, 2016, 222: 24-32.

[4]  Wang J, Liu H (co-first author), Huang D, et al. Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. [J]. Applied Microbiology and Biotechnology, 2016.

[5]  Wang B, Liu J, Liu H, et al. Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus, Journal of Industrial Microbiology & Biotechnology, 42(6):949-963, 2015.

[6]  Dang L, Liu J, Wang C, Liu H, Wen J. Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on Genome-scale metabolic model, Journal of Industrial Microbiology & Biotechnology, 2016.

[7]  Wang C, Liu J, Liu H, Wang J, Wen J. A genome-scale dynamic flux balance analysis model of Streptomyces tsukubaensis NRRL18488 to predict the targets for increasing FK506 production. Biochemical Engineering Journal, 2016.

[8]  Geng H, Liu H, Liu J, et al. Insight into the metabolic mechanism of rapamycin overproduction in the shikimic acid-resistance Streptomyces hygroscopicus strain using comparative metabolomics. World Journal of Microbiology and Biotechnology, 2017.

[9]  Wang C, Liu J, Liu H, et al. Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. Journal of Industrial Microbiology & Biotechnology, 2017