Biography

Changlu Wang is a Professor and Ph.D tutor of the College of Food Engineering and Biotechnology and Curator of Library, Tianjin University of Science and Technology (TUST).  Prof. Wang completed Bachelor and Master Degrees from Tianjin Institute of Light Industry (TILI, the predecessor of TUST) at 1983 and 1988 and joined TILI from 1983 to now.  Prof. Wang was a lecturer, associate professor and professor at 1990, 1993 and 1998, respectively. From 2001 to 2009, Prof. Wang was elected as the Director of Postgraduate Department in TUST. From 2013 to the present, Prof. Wang has been acting as the Curator of Library in TUST.

Research Interests

Prof. Wang’s group has rich research experiences and wide research interests including (1) Processing and storage of farm products; (2) Biological transformation and resource development of agricultural and sideline products; (3) Research and development of functional food; (4) Biotransformation of renewable energy; (5) Research and development of biological organic fertilizer; (6) Improvement of traditional fermented food; (7) Functional factors of natural material and microbial metabolic products; (8) Molecular biology of Monascus spp. and Streptomycete spp.

Part of Publications

[1] Chen, D.; Chen, M.H.; Wu, S.F.; Li, Z.J.; Yang, H.; Wang, C.L. The molecular mechanisms of Monascus purpureus M9 responses to blue light based on the transcriptome analysis. Sci Rep, 2017, 7 (1), 5537.

[2] Lin, L.; Wang, C.L.; Li, Z.J.; Wu, H.J.; Chen, M.H. Effect of temperature-shift and temperature-constant cultivation on the Monacolin K biosynthetic gene cluster expression in Monascus sp. Food Technol Biotechnol, 2016, 55 (1), 40-47.

[3] Li, F. J.; Liu, W. L.; Yamaki, K.; Liu, Y. H.; Fang, Y. Y.; Li, Z. J.; Chen, M. H.; Wang, C.L. Angiotensin I-Converting Enzyme Inhibitory Effect of Chinese Soypaste Along Fermentation and Ripening: Contribution of Early Soybean Protein Borne Peptides and Late Maillard Reaction Products. International Journal of Food Properties, 2016, 19 (12), 2805-2816.

[4] Cui, H.Y.; Wu, S.F.; Shang, Y.F.; Li, Z.J.; Chen, M.H.; Li, F.J.; Wang, C.L. Pleurotus nebrodensis polysaccharide(PN50G) evokes A549 cell apoptosis by the ROS/AMPK/PI3K/AKT/mTOR pathway to suppress tumor growth. Food & function, 2016, 7 (3), 1616-1627.

[5] Chen, D.; Xue, Y.; Chen, M.H.; Li, Z.J.; Wang, C.L. Optimization of submerged fermentation medium for citrinin-free monascin production by Monascus. Preparative biochemistry & biotechnology, 2016, 46 (8), 772-779.

[6] Chen, D.; Xue, C.M.; Chen, M.H.; Wu, S.F.; Li, Z.J.; Wang, C.L. Effects of blue light on pigment biosynthesis of Monascus. Journal of microbiology, 2016, 54 (4), 305-310.

[7] Wang, C.L.; Chen, D.; Chen, M.H.; Wang, Y.R.; Li, Z.J.; Li, F.J. Stimulatory effects of blue light on the growth, monascin and ankaflavin production in Monascus. Biotechnology letters, 2015, 37 (5), 1043-1048.

[8] Cui, H. Y.; Wang, C.L.; Wang, Y. R.; Li, Z. J.; Zhang, Y. N. The polysaccharide isolated from Pleurotus nebrodensis (PN-S) shows immune-stimulating activity in RAW264.7 macrophages. Chinese Journal of Natural Medicines, 2015, 13 (5), 355-360.

[9] Cui, H. Y.; Wang, C.L.; Wang, Y. R.; Li, Z. J.; Chen, M. H.; Li, F. J.; Sun, Y. P. Pleurotus nebrodensis polysaccharide (PN-S) enhances the immunity of immunosuppressed mice. Chin J Nat Med, 2015, 13 (10), 760-766.

[10] Wang, C.L.; Cui, H.Y.; Wang, Y.R.; Wang, Z.F.; Li, Z.J.; Chen, M.H.; Li, F.J. Bidirectional immunomodulatory activities of polysaccharides purified from Pleurotus nebrodensis. Inflammation, 2014, 37 (1), 83-93.

[11] Cui, H.Y.; Wang, C.L.; Wang, Y.R.; Li, Z.J.; Zhang, Y.N.; Chen, M.H.; Li, F.J. Pleurotus nebrodensis polysaccharide induces apoptosis in human non-small cell lung cancer A549 cells. Carbohydrate polymers, 2014, 104, 246-252.

[12] Zhang, X. W.; Li, P. R.; Wang, C.L.; Chen, M. H.; Li, Z. J.; Wang, Y. R. Effect of Blue Light on the Growth, Culture Morphology, and Pigment Production of Monascus. Journal of Pure And Applied Microbiology, 2013, 7, 671-678.

[13] Wang, Z.F.; Wang, C.L.; Li, F.J.; Li, Z.J.; Chen, M.H.; Wang, Y.R.; Qiao, X.; Zhang, H. Fumigant activity of volatiles from Streptomyces alboflavus TD-1 against Fusarium moniliforme Sheldon. Journal of microbiology, 2013, 51 (4), 477-483.

[14] Wang, C.L.; Wang, Z.F.; Qiao, X.; Li, Z.J.; Li, F.J.; Chen, M.H.; Wang, Y.R.; Huang, Y.; Cui, H. Antifungal activity of volatile organic compounds from Streptomyces alboflavus TD-1. FEMS microbiology letters, 2013, 341 (1), 45-51.

[15] Li, Y.D.; Frenz, C. M.; Li, Z.W.; Chen, M.H.; Wang, Y.R.; Li, F.J.; Luo, C.; Sun, J.; bohlin, L.; Li, Z.J.; Yang, H.; Wang, C.L. Virtual and In vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against Xanthine oxidase and Cyclooxygenase-2 for gout treatment. Chemical Biology & Drug Design, 2013, 81,537-544.

[16] Wang, Z.F.; Zhang, H.; Wang, C.L.; Li, Z.J.; Li, F.J.; Chen, M.H.; Wang, Y.R.; Huang, Y.F. Medium Optimization for Active Substance Production of  Streptomyces alboflavus TD-1 Using Response Surface Methodology. Advanced Materials Research, 2013, 683, 250-253.

[17] Wang, C.L.; Yang, H.; Chen, M.H.; Wang, Y.R.; Li, F.J.; Luo, C.; Zhao, S.Y.; He, D. Real-time quantitative analysis of the influence of blue light on citrinin biosynthetic gene cluster expression in Monascus. Biotechnology letters, 2012, 34 (9), 1745-1748.

[18] Wang, C.L.; Li, Z. J.; Li, F. J.; Chen, M. H.; Wang, Y. R.; Li, Y. D.; He, D. Optimization of Microwave Assisted Extraction Conditions for Total Flavonoids in Toona Sinensis Leaves Using Response Surface Methodology. International Journal of Food Engineering, 2012, 8 (4).

[19] Jiang, S.H.; Li, H.Q.; Ma, H.L.; Liao, L.; Wang, Z.B.; Fu, X.; Wang, C.L. Antioxidant activities of selected Chinese medicinal and edible plants. International journal of food sciences and nutrition, 2011, 62 (5), 441-444.

[20] Nie, C.; Wang, C.L.; Zhou, G. T.; Dou, F. J.; Huang, M. M. Effects of malting conditions on the amino acid compositions of final malt. African Journal of Biotechnology, 2010, 9 (53), 9018-9025.

[21] Chen, M. H.; Wang, C.L.; Li, L.; Wang, Y. R.; Jiang, S. H. Retention of Volatile Constituents in Dried Toona sinensis by GC-MS Analysis. International Journal of Food Engineering, 2010, 6 (2).

[22] Jiang, S. H.; Wang, C.L.; Chen, Z. Q.; Chen, M. H.; Wang, Y. R.; Liu, C. J.; Zhou, Q. L.; Li, Z. J. Antioxidant Properties Of the Extract And Subfractions From Old Leaves of toona Sinensisroem (Meliaceae). Journal of Food Biochemistry, 2009, 33 (3), 425-441.

[23] Wei, X. K.; Ding, Q. B.; Zhang, L.; Guo, Y. L.; Ou, L.; Wang, C.L. Induction of nucleoside phosphorylase in Enterobacter aerogenes and enzymatic synthesis of adenine arabinoside. Journal of Zhejiang University. Science. B, 2008, 9 (7), 520-526.

[24] Wei, X. K.; Ding, Q. B.; Ou, L.; Zhang, L.; Wang, C.L. Two-step Enzymatic Synthesis of Guanine Arabinoside. Chinese Journal of Chemical Engineering, 2008, 16 (6), 934-937.

[25] Wang, C.L.; Shi, D. J.; Gong, G. L. Microorganisms in Daqu: a starter culture of Chinese Maotai-flavor liquor. World J Microb Biot, 2008, 24 (10), 2183-2190.

[26] Wang, C.L.; Cao, J. W.; Wang, Y. R.; Chen, M. H.; Chen, Z. Q. Study Progress of Cu, Zn Superoxide Dismutase-From Gene to Function. Progress in Modern Biomedicine, 2008, 5, 940-943.

[27] Wang, C.L.; Cao, J. W.; Tian, S. R.; Wang, Y. R.; Chen, Z. Q.; Chen, M. H.; Gong, G. L. Germplasm resources research of Toona sinensis with RAPD and isoenzyme analysis. Biologia, 2008, 63 (3), 320-326.

Honors & Awards

¨ National Science and Technology Progress (the second prize twice),

¨ Tianjin Awards for Science and Technology Progress (the first prize and the third prize),

¨ Hebei Awards for Science and Technology Progress (the second prize),

¨ National Agriculture, Animal Husbandry and Fishery FENGSHOU Award (the second prize),

¨ China National Light Industry Council Awards for Science and Technology Progress (the third prize),

¨ Tianjin Youth Awards for Science and Technology,

¨ Special Allowance of the State Council.

Teaching

¨ Undergraduate Courses: Microbiology; Experimental Technique in Microbiology,

¨ Graduate Courses: Food Biotechnology; Research Methods and Experimental Design,

¨ Ph.D Courses: Advances in Modern Biotechnology.