Zhenchuan Fan Ph.D, Professor
address:	Yifulou Building, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology, TEDA, Tianjin, 300457, China
email:	fanzhen@tust.edu.cn
phone:	+86 022-60912419

Biography

Dr. Zhenchuan Fan is a Professor of the college of Food Engineering and Biotechnology, Tianjin University of Science and Technology. Dr. Fan completed Doctor Degrees in Biomedical Science (Physiology) from Auburm University of USA. Since 2013, Dr. Fan was employed by Tianjin University of Science & Technology as an professor.

Research Interests

Research on intraflagellar transport is worthy, it showed the molecular mechanism of cilia-related diseases and provided solid theory evidence on how to prevent it. Cilia referred as flagella are microtubule-based organelles which requires intraflagellar transport (IFT) system to bring tubulin and other essential components to the distal tip of cilia. The IFT system are consist of 2 protein complexes including complex A and comolex B. Various cargo proteins were transported by the complexes specifically. When the cilia assmbly or structure defected, the cilia function would be affected and lead to many kinds of human diseases. Cilia and flagella are a classical model system to study cilia protein and signaling pathways on control the assembly and dynamic of cell development.

Recent Publications

[1] Dong B, Hu HH, Li ZF, Cheng RQ, Meng DM, Wang J and Fan ZC. A novel bicistronic expression system composed of the intraflagellar transport protein Gene ift25 and FMDV 2A sequence directs robust nuclear gene expression in Chlamydomonas reinhardtii[J]. Applied Microbiology and Biotechnology, 2017, 101:4227-4245

[2] Dong B, Wu S, Wang J, Liu YX, Peng Z, Meng DM, Huang K, Wu M, Fan ZC.

Chlamydomonas IFT25 is dispensable for flagellar assembly but required to export the BBSome from flagella.[J]. Biology Open, 2017, 6(11):1680.

[3] Dong B, Cheng R Q, Liu Q Y, Wang J, Fan ZC. Multimer of the antimicrobial peptide Mytichitin-A expressed in Chlamydomonas reinhardtii exerts a broader antibacterial spectrum and increased potency.[J]. Journal of Bioscience & Bioengineering, 2017. In press.

[4] Meng DM, Zhang YX, Yang R,Wang J, Zhang XH, Sheng JP,Wang JP, Fan ZC. Arginase participates in the methyl jasmonate-regulated quality maintenance of postharvest Agaricus bisporus fruit bodies, Postharvest Biology and Technology, 2017, 132: 7-14.

[5] Meng DM, Zhao JF, Ling X, Dai HX, Guo YJ, Gao XF, Dong B, Zhang ZQ, Meng X, Fan ZC. Recombinant expression, purification and antimicrobial activity of a novel antimicrobial peptide PaDef in Pichia pastoris, Protein Expression and Purification, 2017, 130: 90-99.

[6] Meng DM, Dai HX, Gao XF, Zhao JF, Guo YJ, Ling X, Dong B, Zhang ZQ, Fan ZC. Expression, Purification and Initial Characterization of a novel recombinant antimicrobial peptide Mytichitin-A in Pichia pastoris, Protein Expression and Purification, 2016, 127: 35-43.

[7] Cheng J, Ma J, Lin J, Fan ZC, Cronan JE and Wang HH. 2012. Only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-ACP synthase homologues functions in fatty acid synthesis. Applied and Environmental Microbiology 78:1563-1573

[8] Fan ZC and Bird RC. 2012. An alternative -1/+2 open reading frame exists within Npro(1-19) region of bovine viral diarrhea virus SD-1. Virus Research 163:341-351

[9] Fan ZC and Bird RC. 2012. Development of a reporter bovine viral diarrhea virus and initial evaluation of its application for high throughput antiviral drug screening. Journal of Virological Methods 180:54-61

[10] Fan ZC, Behal RH, Geimer S, Wang Z, Williamson SM, Zhang H, Cole DG and Qin H. 2010. Chlamydomonas DYF-1 is an IFT particle complex B subunit and required for flagellar assembly. Molecular Biology of the Cell 21:2696-2706

[11] Fan ZC and Bird RC. 2010. The extra 16-amino-acid peptide at C-terminal NS2 of the hypervirulent type-2 bovine viral diarrhea viruses has no effect on viral replication and NS2-3 processing of type-1 virus. Virus Genes 41:218-223

[12] Fan ZC and Tao YX. 2009. Functional characterization and pharmacological rescue of human melanocortin-4 receptor mutants identified from obese patients. Journal of Cellular and Molecular Medicine 13:3268-3282

[13] Wang Z, Fan ZC, Williamson S and Qin H. 2009. Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of the IFT complex B and physically interacts with IFT27 in Chlamydomonas. PLoS ONE 4(5):e5384

[14] Fan ZC and Tao YX. 2009. Functions of transmembrane domain 6 in human melanocortin-4 receptor. FASEB Journal 23 (Suppl.) 943.4

[15] Roth CL, Ludwig M, Woelfle J, Fan ZC, Biebermann H and Tao YX. 2009. A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity. Endocrine 13:1123-1133

[16] Fan ZC and Wang HH. 2009. Regeneration and characterization of a recombinant bovine viral diarrhea virus and determination of its efficiency to cross the bovine placenta. Virus Genes 38:129-135

[17] Fan ZC, Sartin JL and Tao YX. 2008. Pharmacological analyses of two porcine melanocortin-4 receptor mutants in domestic pigs. Domestic Animal Endocrinology 34:383-390

[18] Fan ZC, Sartin JL and Tao YX. 2008. Molecular cloning and pharmacological characterization of the porcine melanocortin-3 receptor. Journal of Endocrinology 196:139-148

[19] Fan ZC, Dennis JC and Bird RC. 2008. Bovine viral diarrhea virus is a suitable viral vector for stable expression of heterologeous gene when inserted in between Npro and C genes. Virus Research 138:97-104

[20] Wang SX, Fan ZC and Tao YX. 2008. Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation. Biochemical Pharmacology 154:223-230

[21] Fan ZC and Bird RC. 2008. Generation and characterization of an Npro-disrupted marker bovine viral diarrhea virus derived from a BAC cDNA. Journal of Virological Methods 151:257-263

[22] Fan ZC and Bird RC. 2008. An improved reverse genetics system for generation of bovine viral diarrhea virus as a BAC cDNA. Journal of Virological Methods 149:309-315

[23] Ge SC, Fan ZC, Chen XS and Yang SS. 2001. Subcloning and sequencing of DNA fragment related to salt tolerance in Sinorhizobium Meliloti 042B. Acta Microbiologica Sinica 41:9-15 (中文)

[24] Wang HH, Fan ZC and Yang SS. 2000. Screening salt tolerant mutant and salt dependent mutants of moderate Halophile B5. Journal of Shanxi Agricultural University 20:64-67 (In Chinese)

[25] Fan ZC, Wang HH, Ge SC and Yang SS. 2000. Identification of the promoter region in the putative tnpA of Halomonas sp. C6 by employing the reporter gene gfp. Journal of Agricultural Biotechnology  8:412-416 (In Chinese)

[26] Wang HH, Fan ZC, Zeng J and Yang, SS. 1999. The antibiotic resistance of a plasmid regulated by osmotic pressure from Halomonas sp. C6. Journal of Agricultural Biotechnology 7:366-372 (In Chinese)

[27] Wang HH, Fan ZC, Zeng J and Yang SS. 1999. Cloning and sequencing of the DNA fragment related to salt tolerance of Halomonas sp. C6. Journal of Agricultural Biotechnology 7:271-276 (In Chinese)

Teaching

 Food Nutrition, Molecular Biology, Gene Engineering for undergraduate students