Dr. Xiaojia Bai is an associate professor of the college of Food Engineering and Biotechnology, Tianjin University of Science and Technology. She completed Bachelor and Master Degrees from Tianjin University of Science and Technology at 1997 and 2000 respectively, and joined this university since 2000, as lecture and associate professor, respectively. Dr. Bai received her doctoral degree from Tianjin University at 2010. She have published over 30 scientific papers.
Research Interests
Development of functional probiotic is important in food micro-organisms research. Cholesterol-lowering effect of lactobacillus by cholesterol assimilation has attract people's attention gradually, but the molecular mechanisms remain unclear, which limits the development and application of strain. Our research group focus on isolation of strain of functional lactobacillus, which can significantly reduce cholesterol content in the medium, and significantly change content of unsaturated fatty acids in cell. Cholesterol-lowering effect of this kind of strains affected by the degree of cholesterol stress in the medium. This research area include construction of transposon mutant library by using transposition complex integrated into the genome of certain strain. After phenotype screening selection, mutants will be obtained which can significantly change the cholesterol-assimilating function of bacillus. Using chromosome walking techniques, get both flanking DNA sequence of the transposon insertion sites in the genome of mutant. Construct gene knockout strain and complete genetic complementation test, thus validate function of gene. Identify regulation of key gene transcription in response to cholesterol stress. The work of our group will preliminary clarify the molecular mechanism of cholesterol-lowering effect of lactobacillus.
Recent Publications
[1] Bai Xiaojia, Dong jian. Serine214 of Ras2p plays a role in the feedback regulation of the Ras-cAMP pathway in the yeast Saccharomyces cerevisiae[J]. FEBS Letters. 2010, 584: 2333-2338. (SCI)
[2] Dong. Jian, Zhang. Aili, Bai Xiaojia, Zhao. Huansheng, Hu. Yun. Feedback regulation of Ras2 guanine nucleotide exchange factor (Ras2-GEF) activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces cerevisiae[J]. FEBS Letters. 2011,584: 4745-4750.(SCI)
[3] Yun Hu, Enkai Liu, Xiaojia Bai and Aili Zhang. The localization and concentration of the PDE2-encoded high affinity cAMP phosphodiesterase is regulated by cAMP-dependent protein kinaseA in the yeast Saccharomyces cerevisiae[J]. FEMS Yeast Res. 2010, 10: 177–187. (SCI)
[4] Yanping Wang, Nv Xu, Aodeng Xi, Zaheer Ahmed, Bin Zhang, Xiaojia Bai. Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet[J]. Appl Microbiol Biotechnol. 2009, 84: 341-347. (SCI)
[5] Yanping Wang, Chao Li, Peng Liu, Zaheer Ahmed, Ping Xiao, Xiaojia Bai (2010). Physical characterization of exopolysaccharide produced by Lactobacillus plantarum KF5 isolated from Tibet Kefir[J]. Carbohydrate Polymers. 2010, 82:895-903 .(SCI)
[6] Yanping Wang, Qiaoling Cheng, Zaheer Ahmed, Xiaoxue Jiang, and Xiaojia Bai. Purification and partial characterization of milk-clotting enzyme extracted from glutinous rice wine mash liquor. Korean J.Chem. Eng. 2009.26(5)：1313-1318. (SCI)
[7] Songrong Zeng, Yanping Wang, Xiaojia Bai, et al. Determination of meaty peptide in enzymatic hydrolyzate of beef protein by HPLC-MS. Korean J. Chem. Eng. 2008, 25: 1120-1124. (SCI)
[8] Xiaojia Bai, Qi Meng, Baochi Zhang, Yanping Wang. Constitutive expression of Beefy Meaty Peptide in Pichia pastoris using the GAP Promoter. 15th symposium of Young Asian Biochemical Engineers’ Community, Xiamen, 2009.12
[9] Xiaojia Bai, Yanping Wang. Study on the antibacterial effect of poly-phenol extracts of apple. 14th world Congress of Food Science and Technology, 2008.10
[10] Xiaojia Bai, Weili Lin, Yanglei, et al. Determination of Beefy Meaty Peptide in Beef Protein Hydrolysates with Proteases by HPLC-MS，13th symposium of Young Asian Biochemical Engineers’ Community，Korea，2007.10
Honors & Awards
ü1th My Favorite Teacher, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology
ü2th My Favorite Teacher, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology
ü3rd Scientific and Technological Progress Award from Tianjin Municipal Science and Technology Commission
Teaching
Biochemistry and Biochemistry Experiment for undergraduate students
